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A note from our team...
If you have found your way here it means you are a diligent advocate for either your health or someone you love. You may be a woman with PCOS (polycystic ovarian syndrome) or you may have read some of the cutting edge (currently experimental) theories about D-chiro-inositol's impact on a variety of maladies. While we are certainly excited about the possibilities of DCI’s potential we have a strict policy of only touting benefits that have been proven in human (in vivo) clinical trials. Currently, only PCOS is in that category.
Whatever brought you here we are glad you found us and we are happy to discuss the latest research and help you decide if DCI is right for you. As mentioned, successful clinical trials have shown that many women can relieve their PCOS by allowing their bodies to dispose of sugar naturally and effectively.
What is DCI?
DCI (D-Chiro-Inositol) is what is known as a secondary messenger in the insulin signaling process and is considered an insulin sensitizer.
When you eat food, sugar is extracted and goes into your blood
Your pancreas releases insulin in response to the sugar
The insulin tells the cells of your body to either burn the sugar for energy or to store it as fat for later
As the sugar level goes down, the insulin level goes down as well
Insulin doesn't communicate directly with the cells, however... It communicates through a secondary messenger made out of DCI
Another important thing that happens to women when there is insulin in your blood: the ovaries release testosterone in response to the insulin.
This is natural. As the sugar is disposed of, the insulin level goes down and the ovaries stop releasing testosterone.
DCI is not abundant in diet. It is scarce in foods, so your body must make it from myo-inositol, which is abundant in many foods.
But, the transformation is a complicated process with many steps that some people are not able to do very well. As a result, they don't have enough DCI and the sugar doesn't get disposed of quickly.
How Myo-Inositol becomes D-Chiro-Inositol
The following chart shows, in a simplified way, the steps involved in converting myo to DCI.
Keep in mind that each of the steps shown has multiple sub-steps, and that multiple enzymes are required for each step.
The point being, there are lots of ways that this can go wrong.
If you don't have enough DCI, the insulin level stays high, which means that the ovaries keep producing testosterone. This high level of testosterone is the origin of many of the signs and symptoms of PCOS—anovulation (not ovulating), irregular or absent periods, ovarian cysts, unwanted body hair, hair loss, belly fat, acne, infertility, etc.
For many women with PCOS, DCI can solve these problems by allowing the body to dispose of sugar effectively.
DCI can allow the body to dispose of sugar effectively. Each bottle contains 60 capsules of 600 mg PURE D-chiro-inositol made from carob not soy.VIEW PRODUCT
Have more questions?
Here are some answers.
D-chiro-inositol (DCI) is a member of the B vitamin family. Most people naturally synthesize enough DCI as a part of healthy metabolism, making it from pinitol and myo-inositol, substances abundant in our diets and closely-related to D-chiro-inositol.
The word "inositol" refers to a family of closely related substances and often refers to the most common available form, myo-inositol.
D-chiro-inositol is a very special member of that family. The body needs DCI when responding to insulin, and DCI is difficult to get from diet. Therefore, the human body has to make DCI. Some people's bodies are not efficient at making DCI, and they can develop symptoms of insulin resistance.
DCI is what is known as a secondary messenger in the insulin signaling process and is considered an insulin sensitizer.
When you eat food, sugar is extracted and goes into your blood. Your pancreas releases insulin in response to the sugar. The insulin tells the cells of your body to either burn the sugar for energy or to store it as fat for later.
As the sugar level goes down, the insulin level goes down as well. Insulin doesn't communicate directly with the cells, however. It communicates through a secondary messenger made out of DCI.
DCI is not abundant in diet. It is scarce in foods, so your body must make it from myo-inositol, which is abundant in many foods.
But, the transformation is a complicated process with many steps that some people are not able to do very well.
As a result, they don't have enough DCI and the sugar doesn't get disposed of quickly.
DCI is not only for PCOS. However, There are really not enough human clinical studies, at this time, to tout these other benefits. But suffice to say we have a significant portion of long-term customers that DO NOT have PCOS.
Inositol functions as a secondary messenger for serotonin and dopamine, neurotransmitters that send signals back and forth between the brain and other systems in the body. Low levels of inositol may disrupt this signaling, possibly resulting in mood disorders and impaired mental health.
Some cutting-edge physicians are excited about the research that points to DCI as important in initiating and promoting autophagy, which is a cellular housekeeping process that appears to help prevent some serious mental ailments.
We are excited to see future study results.
Yes, D-chiro-inositol (DCI) is a safe and healthy human metabolite. The Dietary Supplement Health and Education Act of 1994 (DSHEA) defines D-chiro-inositol as a nutritional supplement because it is a natural human metabolite and it is taken orally.
Like all human metabolites, vitamins and minerals included, D-chiro-inositol (DCI) is completely safe and often beneficial when taken in appropriate amounts. DCI is abundant in only a few foods, such as buckwheat ferrinetta, thus making it difficult to get substantial D-chiro-inositol from our diets.
D-chiro-inositol (DCI) is not FDA approved because DCI is an all-natural nutritional supplement. The Food and Drug Administration (FDA) approves drugs as treatments for certain diseases; however, the FDA cannot approve nutritional supplements in the same way.
Instead, the Dietary Supplement Health and Education Act of 1994 (DSHEA) defines whether or not a product is a nutritional supplement. The DSHEA defines D-chiro-inositol (DCI) as a nutritional supplement, and therefore the FDA does not regulate the D-chiro-inositol sold by Chiral Balance.
The Dietary Supplement Health and Education Act of 1994 (DSHEA) states there can be no limits set on the consumption of nutritional supplements. As a result of this legislation, the FDA does not control the sale of nutritional supplements such as vitamins, minerals, and human metabolites such as D-chiro-inositol.
In the original studies of D-chiro-inositol (DCI), DCI was administered in the morning before food. For that reason, Chiral Balance recommends this time of day.
We also recommend taking Chiral Balance DCI with water, because the supplement is a water-soluble nutrient.
Our recommendation—again, based on the major clinical trials—is to take one 600 mg capsule for every 130 pounds of body weight.
That is, is you weigh less than 130 pounds, take one capsule per day; if you weigh between 130 and 260, take take two capsules per day.
It is important to take Chiral Balance DCI on a regular schedule. If you forget or miss a dose, take the missed dose as soon as possible and resume your regular schedule the next day.
Yes. The capsule is made of hypromellose, a vegetable material.
There are few foods that contain significant amounts of DCI. This is why your body must make it from myo-inositol.
The foods with the highest content of DCI are black wheat, soy-lecithin, carob and lentils. Following those are oranges (more concentrated in the skin and pulp and less in the juice), peanuts and beef liver. Finally with a lower content we find buckwheat farinetta and oats.
The amount of these foods you would have to eat to get a therapeutic effect is near impossible on an “average” diet.
Because DCI is so rare in nature, it cannot be easily extracted from plants like myo. Our DCI is made by extracting pinitol (another form of inositol) from carob, then converting the pinitol to DCI.
This is a difficult process that only a few laboratories in the world perform. Corporate companies abandoned DCI when they realized that the cost of mass production, along with the marketing needed to educate the public about it, would put each bottle at hundreds of dollars.
We spend almost nothing on advertising and keep our overhead low so we can make DCI available at this dosage. We truly believe in the positive impact DCI has had on people’s lives.
While the expected risk to the child would be negligible, D-chiro-inositol has never been evaluated in a clinical trial for its use or safety during pregnancy or while breastfeeding.
It is unknown whether it is safe, and therefore the question of whether to use it during pregnancy or while breastfeeding is best made in conjunction with your physician who can help weigh the benefits and risks, such as gestational diabetes.
It is possible. But please understand that we do not present DCI as a weight loss supplement. To do so would be irresponsible.
Whatever benefits you experience from using Chiral Balance D-chiro-inositol will continue as long as you use the supplement as a natural part of healthy metabolism. Any symptoms Chiral Balance D-chiro-inositol has relieved will likely return if you stop taking the supplement.
It may be less likely that DCI will relieve your PCOS. If you developed PCOS later in life as a result of metabolic syndrome, you would probably do better to look at other natural insulin sensitizers.
That is not to say that women with thyroid disorders or metabolic syndrome would see no benefit—some women do—it's just that those problems may not be caused by a lack of DCI.
If you have insulin resistance there is a good chance that DCI will work for you.
If you first noticed signs of PCOS at or soon after puberty, the likelihood of DCI being effective is even greater. If you have diabetic relatives? Even greater.
Yes - Especially if you have insulin resistance!
D-chiro-inositol can be found in every tissue in the body. Different tissues have different amounts.
Overall, the body has less DCI than it does myo-inositol.
DCI is used in several "signaling pathways", which are how the body orchestrates important activities, like the menstrual cycle and ovulation.
DCI is a crucial part of the insulin signaling pathway.
DCI balances and complements the functions of myo-inositol - both are crucial to good health.
Experimental and anecdotal uses are reporting very interesting uses as a complementary therapy to treat a wide range of medical conditions, including Autism and Panic disorders https://pubmed.ncbi.nlm.nih.gov/7793450/
Inositol also has antioxidant properties that fight the damaging effects of free radicals in the brain, circulatory system, and other body tissues.
Some foods are quite rich in myo-inositol, like Cantaloupe for instance. However, D-chiro-inositol is not abundant in the typical diet.
Additionally, there are people who struggle to make the conversion from myo to DCI effectively.
The early works of Joseph Larner and John Nestler showed DCI was important in insulin signaling. https://pubmed.ncbi.nlm.nih.gov/12852758/
DCI was later shown to be important in polycystic ovary syndrome (PCOS). https://pubmed.ncbi.nlm.nih.gov/20156067/
Early research showed DCI was beneficial for women with PCOS. https://pubmed.ncbi.nlm.nih.gov/10219066/
Now we are seeing some amazing anecdotal and experimental case studies in its use with Diabetes, Autism, Alzheimer’s disease, Obsessive Compulsive Disorder (OCD), Panic Disorders, and Autophagy.
The early literature was all positive, for example, DCI improved ovulation, hormones and more in Women with Polycystic Ovary Syndrome (wwPCOS).
Later literature was less clear, but several of these studies that muddied the waters were poorly conducted and riddled with commercial bias.
The most recent information in the literature again sets DCI in a favorable light. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463048/
A variety of doses have been studied. We offer 600 mg capsules because of the clinical trials we feel are the most compelling, and the relief from symptoms our customers get at this dosage. We recommend 1 capsule for every 130lbs of body weight.
Who: We want to provide an option for people that want to explore DCI’s more experimental uses and women with PCOS that find the 40:1 (myo:dci) ratio doesn’t work for them.
- wwPCOS who are trying to improve metabolic parameters should try DCI.
- wwPCOS who are trying to lower male androgens (hair loss, acne, high testosterone) should try DCI.
- wwPCOS who are trying to get pregnant naturally (without assistive reproductive technology like IVF) should try DCI.
- wwPCOS who are trying to get pregnant via assisted reproductive technology (IVF) may benefit from myo or DCI, as both can address insulin resistance that often leads to reproduction issues. However, if you are concerned about the studies that point to “High Dose DCI'' affecting oocyte quality then perhaps the natural route is not for you at this time. While we are dubious about the scientific strength of those studies - we are not the ones going through a very expensive and emotionally taxing experience such as IVF. There are studies that say very different things on this subject, so it would be wrong of us to take a firm stance. Until more studies are done on all inositols and PCOS in general, it may just be better to work closely with your doctor and ask about other ways in which you might address your insulin resistance and/or PCOS symptoms.
Here are some studies on this subject:
- High dose of d-chiro-inositol improves oocyte quality in women with polycystic ovary syndrome undergoing ICSI: a randomized controlled trial: https://pubmed.ncbi.nlm.nih.gov/31657275/
- Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. https://pubmed.ncbi.nlm.nih.gov/21608442/
- How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin https://www.hindawi.com/journals/ije/2016/4987436/