Research Reviews

Critical reviews of research related to PCOS.

A Guide to Researching PCOS
Techniques for finding and evaluating PCOS articles and research.

Myo vs. DCI Egg Quality Study
A review of: "Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial"; European Review for Medical and Pharmacological Sciences, 2011

Landmark Study of DCI in Obese PCOS Women
A review of: "Effects Of D-Chiro-Inositol In Lean Women With The Polycystic Ovary Syndrome"; Endocrine Practice, 2002

Study of DCI in "Lean" PCOS Women
How are they different? Which one is right for me?
A comparison of the uses of myo and DCI in PCOS and metabolic syndrome

Is there clinical evidence that supports DCI therapy for PCOS?

Here are some scientific papers on DCI that you can read online for free:

A clinical trial published by New England Journal of Medicine:
Nestler JE, Jakubowicz DJ, Reamer P, Gunn RD, Allan G (1999). Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. N. Engl. J. Med. 340 (17): 1314-20.

Two papers on DCI insulin signaling:
Larner J. D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistance. Int J Exp Diabetes Res. 2002;3(1):47-60.

Cheang KI, Baillargeon JP, Essah PA, et al. Insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndrome. Metab Clin Exp. 2008;57(10):1390-7.

Myo-inositol content paper:
Clements RS, Darnell B. Myo-inositol content of common foods: development of a high-myo-inositol diet. Am J Clin Nutr. 1980;33(9):1954-67.

An animal study that shows DCI is more effective when taken with manganese:
Fonteles MC, Almeida MQ, Larner J. Antihyperglycemic effects of 3-O-methyl-D-chiro-inositol and D-chiro-inositol associated with manganese in streptozotocin diabetic rats. Horm Metab Res. 2000;32(4):129-32.

The following papers are not free, but you can read the abstracts (ie, summaries of the research and conclusions):

A clinical trial in women with "lean" PCOS, published in Endocrine Practice:
Luorno MJ, Jakubowicz DJ, Baillargeon JP, et al (2002). Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome. Endocrine practice 8 (6): 417-23.

Another paper on DCI insulin signaling in women with PCOS:
Nestler JE, Jakubowicz DJ, Iuorno MJ (2000). Role of inositolphosphoglycan mediators of insulin action in the polycystic ovary syndrome. J. Pediatr. Endocrinol. Metab. 13 Suppl 5: 1295-8.

A recent clinical trial in which 500 mg of DCI per day was trialed:
Genazzani AD, Santagni S, Rattighieri E, et al. Modulatory role of D-chiro-inositol (DCI) on LH and insulin secretion in obese PCOS patients. Gynecol Endocrinol. 2014;30(6):438-43.

A recent clinical trial that showed improved menstrual regularity with DCI:
La marca A, Grisendi V, Dondi G, Sighinolfi G, Cianci A. The menstrual cycle regularization following D-chiro-inositol treatment in PCOS women: a retrospective study. Gynecol Endocrinol. 2015;31(1):52-6.