The short answer is that DCI is not known to interfere with any medications. We don't recommend you take it with androgen antagonists, but only because they may both work too well.
We always recommend you speak to your doctor before combining any supplement with prescription drugs. The following is for informational purposes only:
Spironolactone (brand names: Aldactone and Spiractin) is an aldosterone antagonist and moderates responsiveness to androgens as well. The medication is often prescribed to manage some of the symptoms of PCOS related to hyperandrogenism, such as hirsutism, androgenic alopecia, and acne. Spironolactone is an anti-diuretic. The medication's anti-androgenic effects are secondary and result from competitively binding to androgen receptors, thereby preventing testosterone and dihydrotestosterone from acting. The drug has side effects.
DCI addresses hyperandrogenism by restoring insulin sensitivity, while Spironolactone addresses the elevated testosterone. Their very distinct mechanisms suggest little likelihood for interaction. However, we do not recommend that you take DCI with spironolactone or other androgen antagonists unless directed by your physician.